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Article

Nck adaptor proteins control the organization of neuronal circuits important for walking.

Proceedings of the National Academy of Sciences of the United States of America - 26 Dec 2007

Fawcett James P, Georgiou John, Ruston Julie, Bladt Friedhelm, Sherman Andrew, Warner Neil, Saab Bechara J, Scott Rizaldy, Roder John C, Pawson Tony

Abstract excerpt

The intracellular signaling targets used by mammalian axon guidance receptors to organize the nervous system in vivo are unclear. The Nck1 and Nck2 SH2/SH3 adaptors (collectively Nck) can couple phosphotyrosine (pTyr) signals to reorganization of the actin cytoskeleton and are therefore candidate...

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Identifiers

PMID: 18093944
DOI: 10.1073/pnas.0710316105
PMCID: PMC2409251

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18093944-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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