Article
EphA4 (Sek1) receptor tyrosine kinase is required for the development of the corticospinal tract.
Proceedings of the National Academy of Sciences of the United States of America - 27 Oct 1998
Dottori M, Hartley L, Galea M, Paxinos G, Polizzotto M, Kilpatrick T, Bartlett P F, Murphy M, Köntgen F, Boyd A W
Abstract excerpt
Members of the Eph family of tyrosine kinase receptors have been implicated in the regulation of developmental processes and, in particular, axon guidance in the developing nervous system. The function of the EphA4 (Sek1) receptor was explored through creation of a null mutant mouse. Mice with a null mutation in the EphA4 gene are viable and fertile but have a gross motor dysfunction, which is evidenced by a loss...
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