Article
Forward signaling mediated by ephrin-B3 prevents contralateral corticospinal axons from recrossing the spinal cord midline.
Neuron - 1 Jan 2001
Yokoyama N, Romero M I, Cowan C A, Galvan P, Helmbacher F, Charnay P, Parada L F, Henkemeyer M
Abstract excerpt
To investigate Eph-ephrin bidirectional signaling, a series of mutations were generated in the ephrin-B3 locus. The absence of both forward and reverse signaling resulted in mice with mirror movements as typified by a hopping locomotion. The corticospinal tract was defective as axons failed to respect the midline boundary of the spinal cord and bilaterally innervated both contralateral and ipsilateral motor...
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