Article
Cep97 and CP110 suppress a cilia assembly program.
Cell - 24 Aug 2007
Spektor Alexander, Tsang William Y, Khoo David, Dynlacht Brian David
Abstract excerpt
Mammalian centrioles play a dynamic role in centrosome function, but they also have the capacity to nucleate the assembly of cilia. Although controls must exist to specify these different fates, the key regulators remain largely undefined. We have purified complexes associated with CP110, a protein that plays an essential role in centrosome duplication and cytokinesis, and have identified a previously...
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