Article

CPAP/CENPJ is essential for the stability and function of ESCRT-pathway associated AAA+ ATPase VPS4B

2026-06-02

Abstract excerpt

Function of CENPJ/CPAP is essential for centriole duplication and cilia biogenesis, disruption of which can lead to microcephaly and Seckel syndrome. Recently, we showed that CPAP is an integral Endosomal Sorting Complexes Required for Transport (ESCRT)-0-like protein that recruits ESCRT-I protein TSG101 to early endosome (EE) and it positively regulates multi-vesicular body (MVB) formation. Sequential recruitment...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ac186d13-48b3-50b2-84f6-73b4311016b9
DOI: 10.64898/2026.05.29.728888

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

CPAP/CENPJ is essential for the stability and function of ESCRT-pathway associated AAA+ ATPase VPS4BDOI 10.64898/2026.05.29.728888Read

De Novo VPS4A Mutations Cause Multisystem Disease with Abnormal Neurodevelopment.Semantic proximity Read

Endosomal sorting complex required for transport proteins in cancer pathogenesis, vesicular transport, and non‐endosomal functionsSemantic proximity Read

The human AAA-ATPase VPS4A isoform and its co-factor VTA1 have a unique function in regulating mammalian cytokinesis abscissionSemantic proximity Read

At the crossroads of homoeostasis and disease: roles of the PACS proteins in membrane traffic and apoptosisSemantic proximity Read

Insights into VPS13 properties and function reveal a new mechanism of eukaryotic lipid transport.Semantic proximity Read

ESCRTs and human diseaseSemantic proximity Read

Multiple Ciliary Localization Signals Control INPP5E Ciliary TargetingSemantic proximity Read

CPAP promotes timely cilium disassembly to maintain neural progenitor pool.Semantic proximity Read

Yeast Vps13 promotes mitochondrial function and is localized at membrane contact sites.Semantic proximity Read

Yeast and other lower eukaryotic organisms for studies of Vps13 proteins in health and disease.Semantic proximity Read

TBCK-deficiency leads to compartment-specific mRNA and lysosomal trafficking defects in patient-derived neuronsSemantic proximity Read

VPS13A and VPS13C influence lipid droplet abundanceSemantic proximity Read