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Article

The 4,752 C/T polymorphism in the presenilin 1 gene increases the risk of Alzheimer's disease in apolipoprotein E4 carriers.

Internal medicine (Tokyo, Japan) - 1 Oct 2002

Matsubara-Tsutsui Miho, Yamagata Hidehisa, Morishima Atsuyuki, Nakura Jun, Mitsuda Noriaki, Kamino Kouzin, Kondo Ikuko, Miki Tetsuro

Abstract excerpt

OBJECTIVE: We sought to establish an association between sporadic Alzheimer's disease (AD) and presenilin 1 (PSEN1) gene polymorphisms in the Japanese population. METHODS: A 5 kb fragment containing the putative promoter of the PSEN1 gene for randomly selected control subjects was subcloned into plasmid and sequenced to screen novel polymorphisms in this region. Patients and controls were genotyped for five...

Topics

Alleles
Alzheimer Disease
Apolipoprotein E4
Apolipoproteins E
DNA Mutational Analysis
Gene Frequency
Genotype
Humans
Membrane Proteins
Polymerase Chain Reaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Genetic

Presenilin-1

Risk Factors

Source

Identifiers

PMID: 12413003
DOI: 10.2169/internalmedicine.41.823

Genes

PSEN1
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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