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Article

Molecular determinants of context-dependent progesterone receptor action in breast cancer

20 Feb 2014

Abstract excerpt

The ovarian steroid hormone, progesterone, and its nuclear receptor, the progesterone receptor, are implicated in the progression of breast cancer. Clinical trial data on the effects of hormone replacement therapy underscore the importance of understanding how progestins influence breast cancer growth. The progesterone receptor regulation of distinct target genes is mediated by complex interactions between the...

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PMID: 24552158
DOI: 10.1186/1741-7015-12-32

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