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Article

The antiprogestin Lonaprisan inhibits breast cancer cell proliferation by inducing p21 expression.

Molecular and cellular endocrinology - 10 Feb 2011

Busia L, Faus H, Hoffmann J, Haendler B

Abstract excerpt

The ovarian steroid hormone progesterone is essential for normal mammary gland physiology but may also play a role in breast cancer. Highly potent and selective antiprogestins may therefore represent a new treatment option for this disease. Here we studied the effects of the new antiprogestin Lonaprisan on the T47D breast cancer cell line. Strong inhibition of cell proliferation and arrest in the G0/G1 phase were...

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Source

Identifiers

PMID: 21138753
DOI: 10.1016/j.mce.2010.11.034

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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