Article
Endophenotypes for psychiatric disorders: ready for primetime?
Trends in genetics : TIG - 1 Jun 2006
Bearden Carrie E, Freimer Nelson B
Abstract excerpt
It is increasingly accepted that the imprecision of categorical psychiatric diagnoses can be a limiting factor in understanding the genetic basis of human behavioral abnormalities. Genetic investigation of endophenotypes--more precisely defined quantitative traits hypothesized to underlie disease syndromes--offers great promise as an alternative or complement to studies of categorical disease phenotypes. However,...
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