Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mapping Risk from Genes to Behavior: The Enduring and Evolving Influence of Irving Gottesman's Endophenotype Concept.

Twin research and human genetics : the official journal of the International Society for Twin Studies - 1 Aug 2018

Dick Danielle M

Abstract excerpt

One of Irving I. Gottesman's many contributions to behavior genetics, and part of his enduring legacy, was his introduction of the term 'endophenotype' to the field of psychiatry. Gottesman argued that focusing on endophenotypes, rather than complex heterogeneous clinical diagnoses, could help elucidate disease etiology. Although a different strategy for gene identification ultimately proved successful (that of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Behavior
Share to Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mental Disorders

Share to Mental Health

Share to Multifactorial Inheritance

Share to Phenotype

Share to Substance-Related Disorders

Source

Identifiers

PMID: 30027865
DOI: 10.1017/thg.2018.35

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mapping Risk from Genes to Behavior: The Enduring and Evolving Influence of Irving Gottesman's Endophenotype Concept.PMID 30027865Read ↗

Endophenotype 2.0: updated definitions and criteria for endophenotypes of psychiatric disorders, incorporating new technologies and findings.Semantic proximity Read ↗

Endophenotypes in the genetic analyses of mental disorders.Semantic proximity Read ↗

Arguments for the sake of endophenotypes: examining common misconceptions about the use of endophenotypes in psychiatric genetics.Semantic proximity Read ↗

[Endophenotypes: the molecular biology point of view].Semantic proximity Read ↗

Bringing genetics back to psychiatric endophenotypes.Semantic proximity Read ↗

The endophenotype concept in psychiatry: etymology and strategic intentions.Semantic proximity Read ↗

Endophenotypes as quantitative risk factors for psychiatric disease: rationale and study design.Semantic proximity Read ↗

Endophenotypes for psychiatric disorders: ready for primetime?Semantic proximity Read ↗

The endophenotype concept in psychiatric genetics.Semantic proximity Read ↗

The feasibility of genetic dissection of endophenotypes.Semantic proximity Read ↗

Understanding the genetic architectonics of complex CNS traits: Lost by the association, but found in the interaction?Semantic proximity Read ↗

[Endophenotype--a new concept for biological characterization of psychiatric disorders].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.