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Article

Physical and functional interactions between Werner syndrome helicase and mismatch-repair initiation factors

22 Aug 2007

Abstract excerpt

Werner syndrome (WS) is a severe recessive disorder characterized by premature aging, cancer predisposition and genomic instability. The gene mutated in WS encodes a bi-functional enzyme called WRN that acts as a RecQ-type DNA helicase and a 3'-5' exonuclease, but its exact role in DNA metabolism is poorly understood. Here we show that WRN physically interacts with the MSH2/MSH6 (MutSalpha), MSH2/MSH3 (MutSbeta)...

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PMID: 17715146
DOI: 10.1093/nar/gkm500

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