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Article

Regulation of WRN helicase activity in human base excision repair.

The Journal of biological chemistry - 17 Dec 2004

Ahn Byungchan, Harrigan Jeanine A, Indig Fred E, Wilson David M, Bohr Vilhelm A

Abstract excerpt

Werner syndrome patients are deficient in the Werner protein (WRN), which is a multifunctional nuclear protein possessing 3'-5' exonuclease and ATP-dependent helicase activities. Studies of Werner syndrome cells and biochemical studies of WRN suggest that WRN plays a role in several DNA metabolic pathways. WRN interacts with DNA polymerase beta (pol beta) and stimulates pol beta strand displacement synthesis on a...

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Source

Identifiers

PMID: 15385537
DOI: 10.1074/jbc.M409624200

Genes

WRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulation of WRN helicase activity in human base excision repair.PMID 15385537Read ↗

Selective blockage of the 3'-->5' exonuclease activity of WRN protein by certain oxidative modifications and bulky lesions in DNA.Semantic proximity Read ↗

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Response to Replication Stress and Maintenance of Genome Stability by WRN, the Werner Syndrome ProteinSemantic proximity Read ↗

Diverse dealings of the Werner helicase/nuclease.Semantic proximity Read ↗

Werner syndrome protein: functions in the response to DNA damage and replication stress in S-phase.Semantic proximity Read ↗

Werner syndrome protein contains three structure-specific DNA binding domains.Semantic proximity Read ↗

Research on Werner Syndrome: Trends from Past to Present and Future ProspectsSemantic proximity Read ↗

WRN, the protein deficient in Werner syndrome, plays a critical structural role in optimizing DNA repair.Semantic proximity Read ↗

Coordinate Action of the Helicase and 3′ to 5′ Exonuclease of Werner Syndrome ProteinSemantic proximity Read ↗

Poly(ADP-ribose) polymerase 1 regulates both the exonuclease and helicase activities of the Werner syndrome proteinSemantic proximity Read ↗

Acetylation Regulates WRN Catalytic Activities and Affects Base Excision DNA RepairSemantic proximity Read ↗

The Drosophila orthologue of progeroid human WRN exonuclease, DmWRNexo, cleaves replication substrates but is inhibited by uracil or abasic sites : analysis of DmWRNexo activity in vitro.Semantic proximity Read ↗

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