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Article

Contributions of DNA interstrand cross-links to aging of cells and organisms

26 Nov 2007

Abstract excerpt

Impaired DNA damage repair, especially deficient transcription-coupled nucleotide excision repair, leads to segmental progeroid syndromes in human patients as well as in rodent models. Furthermore, DNA double-strand break signalling has been pinpointed as a key inducer of cellular senescence. Several recent findings suggest that another DNA repair pathway, interstrand cross-link (ICL) repair, might also...

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PMID: 18083760
DOI: 10.1093/nar/gkm1065

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