Article
Genotyping of cytochrome P450 2D6*3 and *4 mutations using conventional PCR.
Clinica chimica acta; international journal of clinical chemistry - 1 Jun 2001
Schur B C, Bjerke J, Nuwayhid N, Wong S H
Abstract excerpt
Cytochrome P450 (CYP450) mixed-function mono-oxygenases, consisting of more than 30 enzymes, are responsible for the metabolism of a large number of drugs and metabolites. With the rapid advances in the human genome project, the role of genetic polymorphism in drug metabolism may become an important adjunct for rational drug therapy, and for the explanation of drug toxicity and interactions. This preliminary...
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