Article
[Molecular genetics of Parkinson's disease].
Brain and nerve = Shinkei kenkyu no shinpo - 1 Aug 2007
Toda Tatsushi
Abstract excerpt
Parkinson's disease (PD) is the second most common neurodegenerative disorder in the world. The occurrence of PD is largely sporadic, while several families with Mendelian segregation of PD have been reported. PD is thought to be caused by mitochondrial dysfunction, oxidative stress and inflammation based on multiple genetic and environmental factors, resulting in the apoptosis of dopaminergic cells. Six causal...
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