The expansion ability but not the quality of HIV-specific CD8(+)  T cells is associated with protective human leucocyte antigen class I alleles in long-term non-progressors.

doi:10.1111/j.1365-2567.2011.03490.x

Article

The expansion ability but not the quality of HIV-specific CD8(+) T cells is associated with protective human leucocyte antigen class I alleles in long-term non-progressors.

Immunology - 1 Nov 2011

López Mariola, Peris Alejandra, Soriano Vincent, Lozano Sara, Vicario José Luis, Rallón Norma I, Restrepo Clara, Benito José M

Abstract excerpt

Studies in long-term non-progressors (LTNP) have suggested that the quality of the CD8(+) response may involve protective human leucocyte antigen (HLA) class I alleles. However, studies examining the expansion ability of different functional CD8(+) T cells and their association with HLA class I alleles are lacking. LTNP, untreated typical progressors (TP) and patients successfully on highly active retroviral...

Topics

Adult
Alleles
Antiretroviral Therapy, Highly Active
CD4 Lymphocyte Count
CD8-Positive T-Lymphocytes
Cell Proliferation
Cells, Cultured
Chemokine CCL4
Female
Gene Frequency

HIV

HIV Infections

HIV Long-Term Survivors

HLA-B Antigens

HLA-B27 Antigen

Humans

Interleukin-2

Male

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