Article
Altered peptide ligand design: altering immune responses to class I MHC/peptide complexes.
Immunological reviews - 1 Jun 1998
Collins E J, Frelinger J A
Abstract excerpt
Class I proteins are responsible for binding proteins from endogenously synthesized proteins and displaying them on the cell surface. Our understanding of this process has reached the point where we can manipulate the biochemical properties of peptide/class I binding and determine the effects of...
Topics
- Antigen Presentation
- Histocompatibility Antigens Class I
- Immunoglobulin Heavy Chains
- Ligands
- Lymphocyte Activation
- Mutation
- Peptides
- Receptors, Antigen, T-Cell
- T-Lymphocytes
- T-Lymphocytes, Cytotoxic