Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Investigating the inhibitory property of DM hCT on hCT fibrillization via its relevant peptide fragments.

Protein science : a publication of the Protein Society - 1 Aug 2023

Chuang Ya-Ping, Chang Yu-Pei, Tu Ling-Hsien

Abstract excerpt

The irreversible aggregation of proteins or peptides greatly limits their bioavailability; therefore, effective inhibition using small molecules or biocompatible materials is very difficult. Human calcitonin (hCT), a hormone polypeptide with 32 residues, is secreted by the C-cells of the thyroid gland. The biological function of this hormone is to regulate calcium and phosphate concentrations in the blood via...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcitonin
Share to Calcium
Share to Mutation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Peptide Fragments

Source

Open in PubMed Open full text

Identifiers

PMID: 37354016
DOI: 10.1002/pro.4711
PMCID: PMC10360389

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Investigating the inhibitory property of DM hCT on hCT fibrillization via its relevant peptide fragments.PMID 37354016Read ↗

Inhibiting Human Calcitonin Fibril Formation with Its Most Relevant Aggregation-Resistant Analog.Semantic proximity Read ↗

Unraveling the underlying mechanisms of reduced amyloidogenic properties in human calcitonin via double mutations.Semantic proximity Read ↗

Both single mutation and molecular conjugation on the mutant prevent calcitonin from forming amyloid fibrils.Semantic proximity Read ↗

Molecular Insights into the Effects of F16L and F19L Substitutions on the Conformation and Aggregation Dynamics of Human Calcitonin.Semantic proximity Read ↗

Specific mutations alter fibrillation kinetics, fiber morphologies, and membrane interactions of pentapeptides derived from human calcitonin.Semantic proximity Read ↗

Secondary structures of human calcitonin at different temperatures and in different membrane-mimicking environments, characterized by circular dichroism (CD) spectroscopySemantic proximity Read ↗

Development of High Affinity Calcitonin Analog Fragments Targeting Extracellular Domains of Calcitonin Family Receptors.Semantic proximity Read ↗

A comparative study of amyloid fibril formation by residues 15-19 of the human calcitonin hormone: a single beta-sheet model with a small hydrophobic core.Semantic proximity Read ↗

Structural diversity of amyloid fibril formed in human calcitonin as revealed by site-directed 13C solid-state NMR spectroscopy.Semantic proximity Read ↗

A role for the C-terminus of calcitonin in aggregation and gel formation: a comparative study of C-terminal fragments of human and salmon calcitonin.Semantic proximity Read ↗

Synthesis and physicochemical studies of amyloidogenic hexapeptides derived from human cystatin C.Semantic proximity Read ↗

Inhibition of the Amyloidogenesis of Transthyretin by Natural Products and Synthetic Compounds.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.