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Article

Structural basis of BMP signalling inhibition by the cystine knot protein Noggin.

Nature - 12 Dec 2002

Groppe Jay, Greenwald Jason, Wiater Ezra, Rodriguez-Leon Joaquin, Economides Aris N, Kwiatkowski Witek, Affolter Markus, Vale Wylie W, Izpisua Belmonte Juan Carlos, Choe Senyon

Abstract excerpt

The interplay between bone morphogenetic proteins (BMPs) and their antagonists governs developmental and cellular processes as diverse as establishment of the embryonic dorsal-ventral axis, induction of neural tissue, formation of joints in the skeletal system and neurogenesis in the adult brain. So far, the three-dimensional structures of BMP antagonists and the structural basis for inactivation have remained...

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PMID: 12478285
DOI: 10.1038/nature01245

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Structural basis of BMP signalling inhibition by the cystine knot protein Noggin.PMID 12478285Read ↗

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