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Article

Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin.

Proceedings of the National Academy of Sciences of the United States of America - 15 Oct 2002

Jin Lei, Harrison Stephen C

Abstract excerpt

Calcineurin (Cn), a Ca(2+)/calmodulin-dependent Ser/Thr protein phosphatase, is an important participant in signaling pathways that activate T cells. It is the target of the immunosuppressive drugs cyclosporin A (CsA) and FK506. These drugs bind proteins known as cyclophilin (Cyp) and FK506-binding protein, respectively, and the drug-protein complexes in turn inhibit Cn. We report the crystal structure of a...

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Identifiers

PMID: 12357034
DOI: 10.1073/pnas.212504399
PMCID: PMC129706

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin.PMID 12357034Read ↗

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Targets of immunophilin‐immunosuppressant complexes are distinct highly conserved regions of calcineurin A.Semantic proximity Read ↗

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Plasmodium falciparum calcineurin and its association with heat shock protein 90: mechanisms for the antimalarial activity of cyclosporin A and synergism with geldanamycin.Semantic proximity Read ↗

The regulatory domains of CNA have different effects on the inhibition of CN activity by FK506 and CsA.Semantic proximity Read ↗

Calcium signalling in T cells stimulated by a cyclophilin B-binding protein.Semantic proximity Read ↗

High activity of the calcineurin A subunit with a V314 deletion.Semantic proximity Read ↗

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