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Article

Huntingtin associates with acidic phospholipids at the plasma membrane.

The Journal of biological chemistry - 28 Oct 2005

Kegel Kimberly B, Sapp Ellen, Yoder Jennifer, Cuiffo Benjamin, Sobin Lindsay, Kim Yun J, Qin Zheng-Hong, Hayden Michael R, Aronin Neil, Scott David L, Isenberg Gerhard, Goldmann Wolfgang H, DiFiglia Marian

Abstract excerpt

We have identified a domain in the N terminus of huntingtin that binds to membranes. A three-dimensional homology model of the structure of the binding domain predicts helical HEAT repeats, which emanate a positive electrostatic potential, consistent with a charge-based mechanism for membrane association. An amphipathic helix capable of inserting into pure lipid bilayers may serve to anchor huntingtin to the...

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Identifiers

PMID: 16085648
DOI: 10.1074/jbc.M503672200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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