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Article

Requirement of an intact microtubule cytoskeleton for aggregation and inclusion body formation by a mutant huntingtin fragment.

Proceedings of the National Academy of Sciences of the United States of America - 22 Jan 2002

Muchowski Paul J, Ning Ke, D'Souza-Schorey Crislyn, Fields Stanley

Abstract excerpt

Huntington's disease is caused by the expansion of CAG repeats coding for a polyglutamine tract in the huntingtin protein. The major pathological feature found in Huntington's disease neurons is the presence of detergent-insoluble ubiquitinated inclusion bodies composed of the huntingtin protein. However, the mechanisms that underlie inclusion body formation, and the precise relationship between inclusion bodies...

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Identifiers

PMID: 11792857
DOI: 10.1073/pnas.022628699
PMCID: PMC117373

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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