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Article

Calcineurin in reactive astrocytes plays a key role in the interplay between proinflammatory and anti-inflammatory signals.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Aug 2007

Fernandez Ana M, Fernandez Silvia, Carrero Paloma, Garcia-Garcia Miguel, Torres-Aleman Ignacio

Abstract excerpt

Maladaptive inflammation is a major suspect in progressive neurodegeneration, but the underlying mechanisms are difficult to envisage in part because reactive glial cells at lesion sites secrete both proinflammatory and anti-inflammatory mediators. We now report that astrocytes modulate neuronal...

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Identifiers

PMID: 17699657
DOI: 10.1523/JNEUROSCI.1002-07.2007
PMCID: PMC6672188

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17699657-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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