Article
Astrocyte activation is suppressed in both normal and injured brain by FGF signaling.
Proceedings of the National Academy of Sciences of the United States of America - 22 Jul 2014
Kang Wenfei, Balordi Francesca, Su Nan, Chen Lin, Fishell Gordon, Hébert Jean M
Abstract excerpt
In the brain, astrocytes are multifunctional cells that react to insults and contain damage. However, excessive or sustained reactive astrocytes can be deleterious to functional recovery or contribute to chronic inflammation and neuronal dysfunction. Therefore, astrocyte activation in response to damage is likely to be tightly regulated. Although factors that activate astrocytes have been identified, whether...
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