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Article

RGC-32 Regulates Generation of Reactive Astrocytes in Experimental Autoimmune Encephalomyelitis.

Frontiers in immunology - 1 Jan 2020

Tatomir Alexandru, Beltrand Austin, Nguyen Vinh, Boodhoo Dallas, Mekala Armugam, Cudrici Cornelia, Badea Tudor C, Muresanu Dafin F, Rus Violeta, Rus Horea

Abstract excerpt

Astrocytes are increasingly recognized as critical contributors to multiple sclerosis pathogenesis. We have previously shown that lack of Response Gene to Complement 32 (RGC-32) alters astrocyte morphology in the spinal cord at the peak of experimental autoimmune encephalomyelitis (EAE), suggesting a role for RGC-32 in astrocyte differentiation. In this study, we analyzed the expression and distribution of...

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Identifiers

PMID: 33569054
DOI: 10.3389/fimmu.2020.608294
PMCID: PMC7868332

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