Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Non-cell autonomous astrocyte-mediated neuronal toxicity in prion diseases

5 Feb 2021

Abstract excerpt

Under normal conditions, astrocytes perform a number of important physiological functions centered around neuronal support and synapse maintenance. In neurodegenerative diseases including Alzheimer's, Parkinson's and prion diseases, astrocytes acquire reactive phenotypes, which are sustained throughout the disease progression. It is not known whether in the reactive states associated with prion diseases,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Neuroinflammation and Neurodegeneration Mechanisms
Share to Prion Diseases and Protein Misfolding

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33546775
DOI: 10.1186/s40478-021-01123-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Non-cell autonomous astrocyte-mediated neuronal toxicity in prion diseasesPMID 33546775Read ↗

The role of astrocytes in prion-like mechanisms of neurodegenerationSemantic proximity Read ↗

The degree of astrocyte activation is predictive of the incubation time to prion diseaseSemantic proximity Read ↗

Functional roles of reactive astrocytes in neuroinflammation and neurodegenerationSemantic proximity Read ↗

Neurodegenerative Diseases: Unraveling the Heterogeneity of Astrocytes.Semantic proximity Read ↗

Senescent and reactive astrocytes display distinct expression profiles and divergent functional capacities.Semantic proximity Read ↗

Protective Functions of Reactive Astrocytes Following Central Nervous System Insult.Semantic proximity Read ↗

Varicose-projection astrocytes: a reactive phenotype associated with neuropathologySemantic proximity Read ↗

Reactive and Senescent Astroglial Phenotypes as Hallmarks of Brain Pathologies.Semantic proximity Read ↗

Region-specific homeostatic identity of astrocytes is essential for defining their reactive phenotypes following pathological insultsSemantic proximity Read ↗

Reactive astrocytes associated with prion disease impair the blood brain barrierSemantic proximity Read ↗

Neurotoxic reactive astrocytes are induced by activated microglia.Semantic proximity Read ↗

Astrocyte Heterogeneity: Impact to Brain Aging and DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.