Article

SRF-deficient astrocytes provide neuroprotection in mouse models of excitotoxicity and neurodegeneration

2023-05-17

Abstract excerpt

Reactive astrogliosis is a common pathological hallmark of central nervous system (CNS) injury, infection, and neurodegeneration, where reactive astrocytes can be protective or detrimental to normal brain functions. Currently, the mechanisms regulating neuroprotective astrocytes and the extent of neuroprotection are poorly understood. Here, we report that conditional deletion of serum response factor (SRF) in adul...

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Literature Corpus work: f6b479e9-cfd5-51ed-b195-ad6c5f39261d
DOI: 10.1101/2023.05.17.541074

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