Article
Astrocyte-associated fibronectin promotes the proinflammatory phenotype of astrocytes through β1 integrin activation.
Molecular and cellular neurosciences - 1 Jun 2023
Chu Pao-Hsien, Chen Shao-Chi, Chen Hsin-Yung, Wu Cheng-Bei, Huang Wei-Ting, Chiang Hou-Yu
Abstract excerpt
Astrocytes are key players in neuroinflammation. In response to central nervous system (CNS) injury or disease, astrocytes undergo reactive astrogliosis, which is characterized by increased proliferation, migration, and glial fibrillary acidic protein (GFAP) expression. Activation of the transcription factor nuclear factor-κB (NF-κB) and upregulation of downstream proinflammatory mediators in reactive astrocytes...
Topics
- Humans
- NF-kappa B
- Fibronectins
- Integrin beta1
- Astrocytes
- Tumor Necrosis Factor-alpha
- Cells, Cultured
- Neuroinflammatory Diseases
- Gliosis
- Phenotype