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Article

Estimating the effectiveness of simian immunodeficiency virus-specific CD8+ T cells from the dynamics of viral immune escape.

Journal of virology - 1 Nov 2007

Mandl Judith N, Regoes Roland R, Garber David A, Feinberg Mark B

Abstract excerpt

Antiviral CD8(+) T cells are thought to play a significant role in limiting the viremia of human and simian immunodeficiency virus (HIV and SIV, respectively) infections. However, it has not been possible to measure the in vivo effectiveness of cytotoxic T cells (CTLs), and hence their contribution to the death rate of CD4(+) T cells is unknown. Here, we estimated the ability of a prototypic antigen-specific CTL...

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Identifiers

PMID: 17699572
DOI: 10.1128/JVI.00946-07
PMCID: PMC2168796

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Source receipt: pubmed, retrieved 7 Sept 2026.

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