Article
What do mathematical models tell us about killing rates during HIV-1 infection?
Immunology letters - 1 Nov 2015
Gadhamsetty Saikrishna, Beltman Joost B, de Boer Rob J
Abstract excerpt
Over the past few decades the extent to which cytotoxic T lymphocytes (CTLs) control human immunodeficiency virus (HIV) replication has been studied extensively, yet their role and mode of action remain controversial. In some studies, CTLs were found to kill a large fraction of the productively infected cells relative to the viral cytopathicity, whereas in others CTLs were suggested to kill only a small fraction...
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