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Article

Mode of growth hormone action in osteoblasts.

The Journal of biological chemistry - 26 Oct 2007

DiGirolamo Douglas J, Mukherjee Aditi, Fulzele Keertik, Gan Yujun, Cao Xuemei, Frank Stuart J, Clemens Thomas L

Abstract excerpt

Growth hormone (GH) affects bone size and mass in part through stimulating insulin-like growth factor type 1 (IGF-1) production in liver and bone. Whether GH acts independent of IGF-1 in bone remains unclear. To define the mode of GH action in bone, we have used a Cre/loxP system in which the type 1 IGF-1 receptor (Igf1r) has been disrupted specifically in osteoblasts in vitro and in vivo. Calvarial osteoblasts...

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Source

Identifiers

PMID: 17698843
DOI: 10.1074/jbc.M705219200

Genes

GHR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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