Article
Growth factor control of bone mass.
Journal of cellular biochemistry - 1 Nov 2009
Canalis Ernesto
Abstract excerpt
Bone formation is determined by the number and function of osteoblasts. Cell number is governed by factors that regulate the replication and differentiation of pre-osteoblasts and factors that regulate osteoblastic cell death. Cell function is controlled by signals acting on the mature osteoblast. Platelet-derived and fibroblast growth factors are bone cell mitogens. Bone morphogenetic proteins (BMPs) and Wnt...
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