FoxO1 is a positive regulator of bone formation by favoring protein synthesis and resistance to oxidative stress in osteoblasts.

Abstract excerpt

Osteoporosis, a disease of low bone mass, is associated with decreased osteoblast numbers and increased levels of oxidative stress within osteoblasts. Since transcription factors of the FoxO family confer stress resistance, we investigated their potential impact on skeletal integrity. Here we employ cell-specific deletion and molecular analyses to show that, among the three FoxO proteins, only FoxO1 is required...

Topics

• Activating Transcription Factor 4
• Animals
• Cell Proliferation
• Cells, Cultured
• Forkhead Box Protein O1
• Forkhead Transcription Factors
• Gene Expression Regulation
• Mice
• Mutation
• Osteoblasts