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JAK2-STAT5B pathway and osteoblast differentiation

22 May 2013

Abstract excerpt

Osteoblast differentiation is a critical step in the maintenance of bone homeostasis. Osteoblast differentiation is generally maintained by growth hormone (GH) and various other endocrine and autocrine/paracrine factors. JAK2-STAT5B pathway is a central axis in the mechanism of GH signaling. Similarly, the autocrine/paracrine signaling factor IGF-1 also mediates its effects through this pathway. Analysis on...

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PMID: 24470975
DOI: 10.4161/jkst.24931

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