Article
Epinephrine is required for normal cardiovascular responses to stress in the phenylethanolamine N-methyltransferase knockout mouse.
Circulation - 28 Aug 2007
Bao Xuping, Lu Chuanyi M, Liu Fujun, Gu Yusu, Dalton Nancy D, Zhu Bo-Qing, Foster Elyse, Chen Ju, Karliner Joel S, Ross John, Simpson Paul C, Ziegler Michael G
Abstract excerpt
BACKGROUND: Epinephrine (EPI) is an important neurotransmitter and hormone. Its role in regulating cardiovascular function at rest and with stress is unclear, however. METHODS AND RESULTS: An epinephrine-deficient mouse model was generated in which the epinephrine-synthesizing enzyme phenylethanolamine N-methyltransferase was knocked out (KO). Blood pressure and heart rate were monitored by telemetry at rest and...
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