Article
Alteration of neurotransmitter phenotype in noradrenergic neurons of transgenic mice.
Molecular endocrinology (Baltimore, Md.) - 1 Nov 1992
Cadd G G, Hoyle G W, Quaife C J, Marck B, Matsumoto A M, Brinster R L, Palmiter R D
Abstract excerpt
The normal complement of neurotransmitters in noradrenergic neurons was altered by expressing the structural gene for the enzyme phenylethanolamine-N-methyltransferase (PNMT) under the control of the dopamine-beta-hydroxylase gene promoter in transgenic mice. This resulted in accumulation of large amounts of epinephrine in neurons of the sympathetic nervous system (SNS) and central nervous system (CNS) but did...
Topics
- Adaptation, Physiological
- Adrenal Glands
- Adrenalectomy
- Adrenergic Fibers
- Animals
- Dopamine beta-Hydroxylase
- Enzyme Induction
- Epinephrine
- Ganglia, Sympathetic
- Genes, Synthetic
- Mice