Article
Absence of gp130 in dopamine beta-hydroxylase-expressing neurons leads to autonomic imbalance and increased reperfusion arrhythmias.
American journal of physiology. Heart and circulatory physiology - 1 Sept 2009
Parrish Diana C, Alston Eric N, Rohrer Hermann, Hermes Sam M, Aicher Sue A, Nkadi Paul, Woodward William R, Stubbusch Jutta, Gardner Ryan T, Habecker Beth A
Abstract excerpt
Inflammatory cytokines that act through glycoprotein (gp)130 are elevated in the heart after myocardial infarction and in heart failure. These cytokines are potent regulators of neurotransmitter and neuropeptide production in sympathetic neurons but are also important for the survival of cardiac myocytes after damage to the heart. To examine the effect of gp130 cytokines on cardiac nerves, we used...
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