Article
Conformation-activity relationship of neuropeptide S and some structural mutants: helicity affects their interaction with the receptor.
Journal of medicinal chemistry - 6 Sept 2007
Tancredi Teodorico, Guerrini Remo, Marzola Erika, Trapella Claudio, Calo Girolamo, Regoli Domenico, Reinscheid Rainer K, Camarda Valeria, Salvadori Severo, Temussi Piero Andrea
Abstract excerpt
Neuropeptide S (NPS) is the endogenous ligand of the previously orphan G-protein coupled receptor now named NPSR. The NPS-NPSR receptor system regulates important biological functions such as sleep/waking, locomotion, anxiety and food intake. Recently, exhaustive Ala scan and d-amino acid scan studies, together with systematic N- and C-terminal truncation, led to the identification of key residues for biological...
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