Article
The activity of prolactin releasing peptide correlates with its helicity.
Biopolymers - 1 May 2013
Deluca Stephanie H, Rathmann Daniel, Beck-Sickinger Annette G, Meiler Jens
Abstract excerpt
The prolactin releasing peptide (PrRP) is involved in regulating food intake and body weight homeostasis, but molecular details on the activation of the PrRP receptor remain unclear. C-terminal segments of PrRP with 20 (PrRP20) and 13 (PrRP8-20) amino acids, respectively, have been suggested to be fully active. The data presented herein indicate this is true for the wildtype receptor only; a 5-10-fold loss of...
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