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Article

Structure of the agonist-bound neurotensin receptor.

Nature - 25 Oct 2012

White Jim F, Noinaj Nicholas, Shibata Yoko, Love James, Kloss Brian, Xu Feng, Gvozdenovic-Jeremic Jelena, Shah Priyanka, Shiloach Joseph, Tate Christopher G, Grisshammer Reinhard

Abstract excerpt

Neurotensin (NTS) is a 13-amino-acid peptide that functions as both a neurotransmitter and a hormone through the activation of the neurotensin receptor NTSR1, a G-protein-coupled receptor (GPCR). In the brain, NTS modulates the activity of dopaminergic systems, opioid-independent analgesia, and the inhibition of food intake; in the gut, NTS regulates a range of digestive processes. Here we present the structure...

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Source

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Identifiers

PMID: 23051748
DOI: 10.1038/nature11558
PMCID: PMC3482300

Genes

NTS
NTSR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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