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PCR Techniques for Clonality Assays

1 Mar 2001

Abstract excerpt

Clonal overgrowths represent the hallmark of neoplastic proliferations, and their demonstration has been proved useful clinically for the diagnosis of malignant lymphomas based on the detection of specific and dominant immunoglobulin and/or T-cell receptor gene rearrangements. Nonrandom genetic alterations can also be used to test clonal expansions and the clonal evolution of neoplasms, especially analyzing...

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PMID: 11277392
DOI: 10.1097/00019606-200103000-00005

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