Article
A high-density SNP genome-wide linkage search of 206 families identifies susceptibility loci for chronic lymphocytic leukemia.
Blood - 1 Nov 2007
Sellick Gabrielle S, Goldin Lynn R, Wild Ruth W, Slager Susan L, Ressenti Laura, Strom Sara S, Dyer Martin J S, Mauro Francesca R, Marti Gerald E, Fuller Stephen, Lyttelton Matthew, Kipps Thomas J, Keating Michael J, Call Timothy G, Catovsky Daniel, Caporaso Neil, Houlston Richard S
Abstract excerpt
Chronic lymphocytic leukemia (CLL) and other B-cell lymphoproliferative disorders display familial aggregation. To identify a susceptibility gene for CLL, we assembled families from the major European (ICLLC) and American (GEC) consortia to conduct a genome-wide linkage analysis of 101 new CLL pedigrees using a high-density single nucleotide polymorphism (SNP) array and combined the results with data from our...
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