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Article

Analysis of a large multi-generational family provides insight into the genetics of chronic lymphocytic leukemia.

British journal of haematology - 1 Jun 2008

Fuller Stephen J, Papaemmanuil Elli, McKinnon Leah, Webb Emily, Sellick Gabrielle S, Dao-Ung Lan-Phuong, Skarratt Kristen K, Crowther Dalemari, Houlston Richard S, Wiley James S

Abstract excerpt

We report the genetic analysis of a large multi-generational family composed of 144 individuals in which 11 members have been diagnosed with chronic lymphocytic leukaemia (CLL). The observation of a significant over-representation of monoclonal B-cell lymphocytosis (MBL) in unaffected family members strongly supports MBL being a surrogate marker of carrier status. A genome-wide linkage scan of the family using...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukemia, Lymphocytic, Chronic, B-Cell

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Identifiers

PMID: 18503587
DOI: 10.1111/j.1365-2141.2008.07188.x

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