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Article

In-silico identification of genetic variants associated with chronic lymphocytic leukemia for diagnostic and therapeutic applications.

Scientific reports - 23 Mar 2026

Islam Md Shariful, Mollah Md Manir Hossain, Ahsan Md Asif, Ali Mohammad, Al Noman Md, Ahmed Md Foysal, Latif Md Abdul, Pal Nibas Kumar, Faysal Md Fahim, Mollah Md Nurul Haque

Abstract excerpt

Chronic Lymphocytic Leukemia (CLL) is a genetically complex and clinically heterogeneous hematologic malignancy characterized by clonal proliferation of mature B-cells. Though a number of genome-wide association analyses (GWAS) have identified several susceptibility loci associated with CLL, much of its inherited risk remains unexplored. In this study, we combined summary statistics of multiple GWAS to identify...

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Topics

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Share to Computer Simulation
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Linkage Disequilibrium

Share to Polymorphism, Single Nucleotide

Share to Protein Interaction Maps

Share to Quantitative Trait Loci

Source

Open in PubMed Open full text

Identifiers

PMID: 41866418
DOI: 10.1038/s41598-026-45456-7
PMCID: PMC13153171

Genes

BCL2
BCL2L11
CASP8
CFLAR
FAS
TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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