Article
A high-density SNP genomewide linkage scan for chronic lymphocytic leukemia-susceptibility loci.
American journal of human genetics - 1 Sept 2005
Sellick Gabrielle S, Webb Emily L, Allinson Ruth, Matutes Estella, Dyer Martin J S, Jonsson Viggo, Langerak Anton W, Mauro Francesca R, Fuller Stephen, Wiley James, Lyttelton Matthew, Callea Vincenzo, Yuille Martin, Catovsky Daniel, Houlston Richard S
Abstract excerpt
Chronic lymphocytic leukemia (CLL) and other B-cell lymphoproliferative disorders (LPDs) show clear evidence of familial aggregation, but the inherited basis is largely unknown. To identify a susceptibility gene for CLL, we conducted a genomewide linkage analysis of 115 pedigrees, using a high-density single-nucleotide polymorphism (SNP) array containing 11,560 markers. Multipoint linkage analyses were undertaken...
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