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Article

The metabolism and dechlorination of chlorotyrosine in vivo.

The Journal of biological chemistry - 5 Oct 2007

Mani Ali R, Ippolito Silvia, Moreno José C, Visser Theo J, Moore Kevin P

Abstract excerpt

During inflammation, neutrophil- and monocyte-derived myeloperoxidase catalyzes the formation of hypochlorous acid, which can chlorinate tyrosine residues in proteins to form chlorotyrosine. However, little is known of the metabolism and disposition of chlorotyrosine in vivo. Following infusion of deuterium-labeled [D(4)]chlorotyrosine into Sprague-Dawley rats, the major urinary metabolites were identified by...

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PMID: 17686770
DOI: 10.1074/jbc.M704270200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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