Article
Identification of thiodiglycolic acid, thiodiglycolic acid sulfoxide, and (3-carboxymethylthio)lactic acid as major human biotransformation products of S-carboxymethyl-L-cysteine.
Drug metabolism and disposition: the biological fate of chemicals - 1 Jan 2000
Hofmann U, Eichelbaum M, Seefried S, Meese C O
Abstract excerpt
S-Carboxymethyl-L-cysteine (CMC) is used both as an orally administered mucolytic agent and as a probe drug for uncovering polymorphic sulfoxidation of other sulfur-containing drugs in humans. However, several recent studies could not confirm the formation of significant amounts of urinary sulfoxides of CMC or its decarboxylation product S-methyl-L-cysteine. The metabolism of CMC and a 13C-labeled isotopomer was...
Topics
- Biotransformation
- Carbocysteine
- Chromatography, Gas
- Humans
- Lactates
- Mass Spectrometry
- Phenotype
- Pyruvates
- Sulfides
- Thioglycolates