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Article

Validation of the chloramine-T induced oxidation of human serum albumin as a model for oxidative damage in vivo.

Pharmaceutical research - 1 Apr 2003

Anraku Makoto, Kragh-Hansen Ulrich, Kawai Keiichi, Maruyama Toru, Yamasaki Yasuomi, Takakura Yoshinobu, Otagiri Masaki

Abstract excerpt

PURPOSE: The validity of using chloramine-T as a model compound for mimicing oxidative stress was examined using human serum albumin (HSA) as a model. Important sites of oxidation were studied by mild treatment with chloramine-T and by mutating 34Cys for a serine (C34S). METHODS: High-performance liquid chromatography (HPLC) combined with fluorescence detection to confirm the validity of chloramine-T as an...

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PMID: 12739779
DOI: 10.1023/a:1023219420935

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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