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Article

sar: a genetic mouse model for human sarcosinemia generated by ethylnitrosourea mutagenesis.

Proceedings of the National Academy of Sciences of the United States of America - 1 Apr 1992

Harding C O, Williams P, Pflanzer D M, Colwell R E, Lyne P W, Wolff J A

Abstract excerpt

A mouse mutant with sarcosinemia was found by screening the progeny of ethylnitrosourea-mutagenized mice for aminoacidurias. Paper chromatography, column chromatography, and gas chromatography-mass spectrometry identified high levels of sarcosine in the urine of the mutant mice. While sarcosine cannot be detected in the urine of plasma of normal mice, the urinary sarcosine level of 102 +/- 58 mmol per g of...

Topics

Amino Acid Metabolism, Inborn Errors
Animals
Ethylnitrosourea
Gas Chromatography-Mass Spectrometry
Mice
Mice, Mutant Strains
Mutagenesis
Oxidoreductases, N-Demethylating
Phenotype
Sarcosine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sarcosine Dehydrogenase

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Identifiers

PMID: 1372986
DOI: 10.1073/pnas.89.7.2644
PMCID: PMC48718

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1372986-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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sar: a genetic mouse model for human sarcosinemia generated by ethylnitrosourea mutagenesis.PMID 1372986Read ↗

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