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Gut microbial phenol impairs energy metabolism and promotes sarcopenic obesity-like phenotypes in mice

2026-06-15

Abstract excerpt

<title>Abstract</title> <p>Gut microbial phenol has been recognized as a uremic toxin associated with chronic kidney disease; however, its effects under preclinical conditions remain unclear. In this study, we established a mouse model with increased endogenous phenol production using a tyrosine-rich diet. High-tyrosine feeding markedly increased fecal phenol and circulating phenyl sulfate (PhS) levels without af...

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Literature Corpus work
8d6d33ee-b407-5348-b126-2d74bbfbb713
DOI
10.21203/rs.3.rs-9765736/v1
Open publication

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